Current Issue: Volume 34, Number 1, 2019

Current Issue 2019-03-06T20:52:44+00:00

Celebrating 50 Years of Orthomolecular Medicine in 2018

The term ‘orthomolecular’ was first used by Linus Pauling in his seminal article, Orthomolecular Psychiatry, published in the journal Science, April 19, 1968. Orthomolecular medicine, as conceptualized by Pauling and established through the pioneering leadership of Abram Hoffer is defined as the therapeutic use of substances that occur naturally in the body. Originally defined in the context of treating and preventing psychiatric diseases, the intent of orthomolecular therapy is to provide the optimal molecular environment for the brain and other tissues by altering the intake of nutrients such as vitamins (and their metabolites), minerals, trace elements, macronutrients, as well as other naturally occurring metabolically active substances.


The International Society for Orthomolecular Medicine
Mailing address: PO Box 99517 O’Connor PO, Toronto, ON Canada M4B 3M9

Website:   E-mail:

J Orthomol Med Archive
The Journal of Orthomolecular Medicine is indexed by British Library Direct, Alt HealthWatch™, WorldCat ( AMED, and Google Scholar.