Orthomolecular Medicine Hall of Fame

Inducted 2004

“I noted that niacinamide (alone or combined with other vitamins) in a thousand patient-years of use has caused no adverse side effects.”

Dr. William Kaufman was among the very first physicians to therapeutically employ megadoses of vitamin B3 (niacin, or niacinamide). He prescribed as much as 5,000 mg of niacinamide daily, in many divided doses, to dramatically improve and restore range of joint motion in arthritic patients. This groundbreaking work remains important to this day. In his 1949 book, The Common Form of Joint Dysfunction, Kaufman published the details of his niacinamide arthritis treatment, which also incorporated the use of vitamin C, thiamin, and riboflavin, all in large doses. He kept meticulous patient records that repeatedly verified the safety and effectiveness of megavitamin therapy.

Over 50 years ago, Kaufman showed remarkable foresight half a century into the future of orthomolecular medicine, describing how the lack of a just a single nutrient can cause diverse diseases, including what is now known as attention-deficit hyperactivity disorder. Charlotte Kaufman lovingly writes of her husband, “He was always ready to help someone else. He truly was a healer and a problem solver. He played the piano; he loved Mozart. He wrote poems, plays, essays, and subscribed to about 30 medical journals, which he read. He practiced medicine in his own way, without regard to fads or fashion. He seemed to know intuitively what the clinical answers were, but he was a thoughtful person who did not make decisions lightly. He was an independent thinker who was constantly studying and learning, not just from the printed word, but from his patients. He really listened to his patients. His main objective was to help people live healthy lives.”

Dr. Kaufman’s bibliography is posted at