Personalized Health Research Services, LLC


Phone: +1-407-951-1624
Type of Practice: Consultation, Research, & Writing
Education/Professional Associations:

PhD, Biochemistry; American Medical Writers Association


W. “Todd” Penberthy, PhD was trained in biochemistry and developmental biology.

He directed biomedical research focused on niacin and NAD biology in models of human disease with particular chosen focus on autoimmune and neurodegenerative diseases.

During this time, he was mentored by Dr. Abram Hoffer, MD, PhD with respect to the current state of our understanding of the biochemical mechanisms of action of niacin and related NAD precursor molecules towards appreciating which indications are likely to be most responsive to high-dose niacin therapy and related NAD precursors: niacin/nicotinic acid, niacinamide, nicotinamide riboside, NMN, and tryptophan. Laboratory research was performed using zebrafish models of human disease to compare NAD precursors.

He writes multiple textbook chapter editions describing the latest research of the vitamins niacin, thiamine, riboflavin, and biotin in the textbooks “Present Knowledge in Nutrition” and “Biochemical, Physiological, and Molecular Aspects of Human Nutrition.”

He is a continuing medical education (CME) writer with experience in integrative psychiatry as well as a wide variety of CME courses for physicians.

Todd regularly attends conferences and provides comprehensive personalized health research consultation to individuals. This involves focus on nutritional the essential molecules (vitamins, minerals, amino acids, fatty acids), sleep health, physical therapy, stress status, diet, food allergies, and other factors.

Working with Great Plains Laboratories, Todd provides assistance in determining toxicity or nutritional or infectious disease status to individuals from their home.


Contributions to Orthomolecular Medicine

Todd has described nutritional approaches to treating multiple sclerosis together with Robert Smith.

Performed basic biochemical research focused on determining the best NAD precursor (vitamin B3 or related; e.g. niacin) for treating various indications.

Co-authored The Vitamin Cure for Arthritis (2015) with Robert Smith

Wrote the forwards to Niacin, the Real Story (2015)

Described the importance of NAD in multiple sclerosis

Written pieces describing the risks of using statins and solutions with niacin as well as using niacin to taper off of benzodiazepines such as Xanax.


  1. Penberthy, W. T., & Smith, R. (2018). Nutritional Approaches Treatments for Multiple Sclerosis. Orthomolecular Medical News Service.
  2. Penberthy, W. T. & Kirkland, J.B. (2020 & 2012). Niacin. Present Knowledge in Human Nutrition. 10th edition, Diane Birt, J W Erdman, I MacDonald, S H Zeisel, eds. Ames, Iowa: International Life Sciences.
  3. Penberthy, W. T., Sadri, M., & Zempleni, J. (2020 & 2012). Biotin. Present Knowledge in Human Nutrition. 10th edition, Diane Birt, J W Erdman, I MacDonald, S H Zeisel, eds.  Ames, Iowa: International Life Sciences.
  4. Penberthy, W.T. (2020 & 2013). Niacin, Riboflavin, and Thiamine, ed. Stipanuk, M.H., Caudill, M.A., eds., Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3rd ed (pp. p.540-564). Elsevier/Saunders.
  5. Penberthy, W. T. (2017). Niacin Rescues Cannibalistic Hamsters: The Historical Significance of 1940s Mandatory Niacin Enrichment. Orthomolecular Medical News Service.
  6. Hu, L., Ibrahim, K., Stucki, M., Frapolli, M.,  Shahbeck, N., Chaudhry, F.A., Gorg, B.,  Haussinger, D., Penberthy, W.T., Ben-Omran, T., & Haberle, J. (2015). Secondary NAD+ Deficiency in the Inherited Defect of Glutamine Synthase. Journal of Inherited Metabolic Disease. 38(6):1075-83.
  7. Penberthy, W. T., & Smith, R. (2015). The Vitamin Cure for Arthritis. A book for laypersons about nutritional approaches to treating arthritis. (p1-237). Basic Health Publications, Incorporated.
  8. Penberthy, W. T., & Saul, A. (2014). Supplements Accelerate Benzodiazepine Withdrawal: A Case Report and Biochemical Rationale.   Orthomolecular Medical News Service. 
  9. Penberthy, W.T. (2013). Ask This Question Before Taking Statins. Orthomolecular Medical News Service.
  10. Penberthy, W. T., & Tsunoda, I. (2009). The Importance of NAD in Multiple Sclerosis. Current Pharmaceutical Design, 15(1): 64-99.
  11. Penberthy, W. T. (2007). Pharmacologic Targeting of IDO-mediated Tolerance for Treating Autoimmune Disease. Current Drug Metabolism. 8: 245-266. REQUEST PDF AND I WILL SEND.