Dr. Naoko Hitosugi specializes in pain management, anti-aging treatments and regenerative medicine. She is currently clinical lecturer of the department of anesthesiology at Dokkyo Medical University Saitama Medical Center. She had extended her research studies at Albert Einstein University North Shore/ Long Island Jewish Hospital (Feistein Institute for Medical Research) in the United States. She presents regularly at the American Academy of Dermatology and focuses on the underlying etiologies of skin disorders and aging.

Dr. Hitosugi is the medical director of both Muse Dermatology and Pain Clinic, and Muse City Clinic, where she provides cutting edge treatments in pain management and regenerative medicine.

Dr. Hitosugi is a member of the Japan Society of Pain Clinicians as well as Japanese Society of Anti-Aging Medicine and Japanese Society for Orthomolecular Medicine.

Her current research focuses on management of chronic pain using adipose derived stem cells followed by multidisciplinary approaches such as multivitamin drip infusion therapy, ozone therapy and photoimmuonotherapy.

Presentation Abstract

The Efficacy of Multidisciplinary approaches in management of Chronic Pain

Management of chronic pain is complex and often accompanied with challenges. Particularly, when there are no more options of the tool to propose, it is stressful for both clinicians and patients who suffer from it. Up to date, nerve blocks and opioid use are the main conventional therapies to reduce and treat severe pain or symptoms. However, complete elimination of pain is hardly achieved.

Recent pain management has adopted multiple interventions such as orthomolecular medicine, oriental herb medicine, acupuncture, hyperthermia, ozone therapy, photoimmunotherapy, and regenerative medicine. In addition to those therapies, rehabilitation is the significant factor to maintain or stabilize the range of motion for the patients. The choice of those treatments can provide psychological benefits for the patients and high quality personalized medical care.

This presentation will focus on evaluating the efficacy and the necessity for multidisciplinary approach in chronic pain. Clinicians and patients should discuss treatment goals that include reducing pain, maximizing function, and improving quality of life. The best outcomes can be achieved when multiple interventions are combined and augmented to treat the symptoms and target the underlying etiology.


Dysbiosis of gut microbiota and acne vulgaris: The role of short chain fatty acids gut in pathogenesis.  Abdelhakim M, Maeno T, Ozaki D and Hitosugi N, et al. Clinical Dermatology 2021 DOI: 10.2388 0/cdoaj-16000218

Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women. Ozaki, D, Kubota, R, Maeno, T. et al. Osteoporos Int 32, 145 – 156 2021. 7/s00198-020-05728-y

Induction of apoptosis by morphine in human tumor cell lines in vitro.  Hatsukari I, Hitosugi N, Ohno R, Hashimoto K, Nakamura S, Satoh K, Nagasaka H, Matsumoto I, Sakagami H. Anticancer Res. 2007 Mar-Apr;27 (2):857-64.PMID: 17 465212

DEC-205-mediated internalization of HIV-1 results in the establishment of silent infection in renal tubular cells. Hatsukari I, Singh P, Hitosugi N, Messmer D, Valderrama E, Teichberg S, Chaung W, Gross E, Schmidtmayerova H, Singhal PC.J Am Soc Nephrol. 2007 Mar:18(3):780-7. doi: 10.1681/ASN.2006121307. Epub 2007 Feb 7.PMID: 17287423

Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation. Messmer D, Hatsukari I, Hitosugi N, Schmidt-Wol fI G, Singhal PC.Mal Med. 2006 Nov-Dec;12(11- 12):284-90. doi: 10.2119/2006 – 00043.Messmer.PMID: 17380193

Morphine modulates monocyte-macrophage conversion phase. Hatsukari I, Hitosugi N, Dinda A, Singhal PC.Cell Immunol. 2006 Jan;239(1):41-8. doi: 10.1016/j. cellimm.2006.03.004. Epub 2006 May 15.PMID: 16698002