About the webinar

Presenter: Lindsay Adrian, ND

The role of choline in the body extends beyond its well-known functions in cell membrane integrity and nerve physiology. Its metabolite, phosphatidylcholine, is also crucial, particularly in memory and cognition. However, choline’s impact goes further, influencing methylation, detoxification, metabolism, and cellular health — processes that are compromised when choline is deficient.

This webinar explores how genetic factors regulate choline and phosphatidylcholine formation, clarifying conditions that lead to insufficiency and identifying situations that contribute to choline depletion. Repletion strategies to support patients in maintaining optimal choline levels are also discussed.

References:

https://lpi.oregonstate.edu/book/export/html/342

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

United States Department of Agriculture. USDA Database for the Choline Content of Common Foods, Release 2. 2008. Available from: http://www.ars.usda.gov/Services/docs.htm?docid=6232. Assessed Apr 1, 2025

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Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166

van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidyl ethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

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van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

Zeisel SH, Klatt KC, Caudill MA. Choline. Adv Nutr. 2018;9(1):58-60. doi:10.1093/advances/nmx004

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

Zeisel SH, Klatt KC, Caudill MA. Choline. Adv Nutr. 2018;9(1):58-60. doi:10.1093/advances/nmx004

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166

van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidyl ethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7

Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166

Gámiz F, Gallo M. A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies. Nutrients. 2021;13(6):1966. Published 2021 Jun 8. doi:10.3390/nu13061966

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Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166

Gámiz F, Gallo M. A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies. Nutrients. 2021;13(6):1966. Published 2021 Jun 8. doi:10.3390/nu13061966

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166

Gámiz F, Gallo M. A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies. Nutrients. 2021;13(6):1966. Published2021Jun8.doi:10.3390/nu13061966

Karner, A. Kocjan, J. Stein, S. Schreiber, G. von Boyen, P. Uebel, C. Schmidt, L. Kupcinskas, I. Dina, F. Zuelch, G. Keilhauer, W. Stremmel First multicenter study of modified release phosphatidylcholine “LT-02” in ulcerative colitis: a randomized, placebo-controlled trial in mesalazine-refractory courses Am. J. Gastroenterol., 109 (2014), pp. 1041-1051

van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidyl ethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

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van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidyl ethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9 Pt B):1558-1572. doi:10.1016/j.bbamem.2017.04.006

United States Department of Agriculture. USDA Database for the Choline Content of Common Foods, Release 2. 2008. Available from: http://www.ars.usda.gov/Services/docs.htm?docid=6232. Assessed Apr 1, 2025

Zeisel SH, Klatt KC, Caudill MA. Choline. Adv Nutr. 2018;9(1):58-60. doi:10.1093/advances/nmx004

Han P, Bidulescu A, Barber JR, Zeisel SH, Joshu CE, Prizment AE, et al. Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study. Cancer Causes Control. 2019; 30: 343354.

Chen X, Qiu W, Ma X, et al. Roles and Mechanisms of Choline Metabolism in Non-Alcoholic Fatty Liver Disease and Cancers. Front Biosci (Landmark Ed). 2024;29(5):182. doi:10.31083/j.fbl2905182

Arias N, Arboleya S, Allison J, et al. The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases.Nutrients. 2020;12(8):2340. Published 2020 Aug 5. doi:10.3390/nu12082340

Zeisel SH, Klatt KC, Caudill MA. Choline. Adv Nutr. 2018;9(1):58-60. doi:10.1093/advances/nmx004

Gámiz F, Gallo M. A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies. Nutrients. 2021;13(6):1966. Published 2021 Jun 8. doi:10.3390/nu13061966

Kansakar U, Trimarco V, Mone P, Varzideh F, Lombardi A, Santulli G. Choline supplements: An update. Front Endocrinol (Lausanne). 2023;14:1148166. Published 2023 Mar 7. doi:10.3389/fendo.2023.1148166