Research Literature on COVID-19 and Nutrients

This webpage includes a selection of research publications pertaining to micronutrients and their biological roles in immune function. Articles are linked to their original source via Digital Object Identifier (DOI); PubMed Identifier (PMID); or Uniform Resource Locator (URL)

Vitamin A

• Vitamin A plasma levels in COVID-19 patients: A prospective multicenter study and hypothesis. Nutrients. 2021; 13(7) – https://doi.org/10.3390/nu13072173

• Role of fat soluble vitamins A and D in the pathogenesis of influenza: A new perspective. Hindawi International Scholarly Research Notes. 2013 – https://doi.org/10.5402/2013/246737

• Vitamin A, immunity, and infection. Clinical Infectious Diseases. 1994; 19(3) – https://doi.org/10.1093/clinids/19.3.489

Vitamin C

• Vitamin C in the treatment of COVID-19. Nutrients. 2021; 13(4) – https://doi.org/10.3390/nu13041172

• Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high performance liquid chromatography-tandem mass spectrometry finding. J Pharm Biomed Anal. 2021; 196 – https://doi.org/10.1016/j.jpba.2021.113927

• Possible application of high-dose Vitamin C in the prevention and therapy of Coronavirus infection. J Glob Antimicrob Resist. 2020; 23 –  https://doi.org/10.1016/j.jgar.2020.09.025

• Overview of the possible role of Vitamin C in management of COVID-19. Pharmacol. Rep. 2020; 71 – https://doi.org/10.1007/s43440-020-00176-1

• The long history of vitamin C: From prevention of the common cold to potential aid in the treatment of COVID-19.  Front Immunol. 2020 –  https://doi.org/10.3389/fimmu.2020.574029

• The role of Vitamin C as adjuvant therapy in COVID-19. Cureus. 2020; 12(11) – https://doi.org/10.7759/cureus.11779
• Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Annals of Intensive Care. 2021; 11 – https://doi.org/10.1186/s13613-020-00792-3

• Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: A retrospective case series study. Annals of Palliative Medicine. 2020 – https://doi.org/10.21037/apm-20-1387

• Vitamin C: An adjunctive therapy for respiratory infection, sepsis and COVID-19. Nutrients. 2020; 12(12) – https://doi.org/10.3390/nu12123760

• The use of IV Vitamin C for patients with COVID-19: A case series. Expert Rev Anti Infect Thera. 2020; 18(12) – https://doi.org/10.1080/14787210.2020.1794819

• The emerging role of Vitamin C in the prevention and treatment of COVID-19. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113286

• Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome. Critical Care. 2020; 24 – https://doi.org/10.1186/s13054-020-03249-y

• Ascorbate as prophylaxis and therapy for COVID-19 – Update from Shanghai and U.S. medical institutions. Glob Adv Health Med. 2020; 9:2164956120934768 – https://doi.org/10.1177/2164956120934768

• Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? Nutrition. 2020 – https://doi.org/10.1016/j.nut.2020.110948

• Intravenous high-dose vitamin C for the treatment of severe COVID-19: Study protocol for a multicentre randomised controlled trial. BMJ Open. 2020 – https://doi.org/10.1136/bmjopen-2020-039519

• Patients with community acquired pneumonia exhibit depleted vitamin C status and elevated oxidative stress. Nutrients. 2020; 12(5) – https://doi.org/10.3390/nu12051318

• Quercetin and vitamin C: An experimental, synergistic therapy for the prevention and treatment of SARS-Cov-2. Frontiers in Immunology. 2020 – https://doi.org/10.3389/fimmu.2020.01451

• Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. PharmaNutrition. 2020; 12 – https://doi.org/10.1016/j.phanu.2020.100190

• Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Medicine in Drug Discovery. 2020; 5 – https://doi.org/10.1016/j.medidd.2020.100028

• Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: A meta-regression analysis. Journal of Intensive Care. 2020; 8(15) – https://doi.org/10.1186/s40560-020-0432-y

• Vitamin C can shorten the length of stay in the ICU: A meta-analysis. Nutrients. 2019; 11(4) – https://doi.org/10.3390/nu11040708

• Vitamin C and infections. Nutrients. 2017; 9(4) – https://doi.org/10.3390/nu9040339

• Extra dose of vitamin C based on a daily supplementation shortens the common cold: A meta-analysis of 9 randomized controlled trials. Biomed Res Int. 2018 – https://doi.org/10.1155/2018/1837634

• Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World Journal of Critical Care Medicine. 2017; 6(1) – https://doi.org/10.5492/wjccm.v6.i1.85

• The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. Journal of Manipulative and Physiological Therapeutics. 1999; 22(8) – https://doi.org/10.1016/S0161-4754(99)70005-9

Vitamin D

• The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. International Journal of Clinical Practice. 2021; 75(11) – https://doi.org/10.1111/ijcp.14675

• Vitamin D endocrine system and COVID-19. JBMR Plus. 2021; 5(12) – https://doi.org/10.1002/jbm4.10576

• Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection. Protein Science. 2021; 30(11) – https://doi.org/10.1002/pro.4190

• Vitamin D metabolites and clinical outcome in hospitalized COVID-19 patients. Nutrients. 2021; 13(7) – https://doi.org/10.3390/nu13072129

• Effects of a 2-week 5000 IU versus 1000 IU vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate COVID-19: A randomized clinical trial. Nutrients. 2021; 13(7): 2170. https://doi.org/10.3390/nu13072170

• Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomized controlled trials. Lancet Diabetes Endocrinology. 2021, 9(5) – https://doi.org/10.1016/S2213-8587(21)00051-6

• The impact of COVID-19 pandemic during 2020-2021 on the vitamin D serum levels in the pediatric population in Warsaw, Poland. Nutrients. 2021; 13(6) – https://doi.org/10.3390/nu13061990

• Bad prognosis in critical ill patients with COVID-19 during short-term ICU stay regarding vitamin D levels. Nutrients. 2021; 13(6) – https://doi.org/10.3390/nu13061988

• Calcifediol treatment and hospital mortality due to COVID-19: A cohort study. Nutrients. 2021; 13(6) – https://doi.org/10.3390/nu13061760

• 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020; 12(5) – https://doi.org/10.3390/nu12051359

• Vitamin D status in adolescents during COVID-19 pandemic: A cross-sectional comparative study. Nutrients. 2021; 13(5) – https://doi.org/10.3390/nu13051467

• Relation between vitamin D and COVID-19 in aged people: A systematic review. Nutrients. 2021; 13(4) – https://doi.org/10.3390/nu13041339

• Impact of COVID-19 pandemic on serum vitamin D level among infants and toddlers: An interrupted time series analysis and before-and-after comparison. Nutrients, 2021; 13(4) – https://doi.org/10.3390/nu13041270

• Notable developments for vitamin D amid the COVID-19 pandemic, but caution warranted overall: A narrative review. Nutrients. 2021; 13(3) – https://doi.org/10.3390/nu13030740

• Lung-centric inflammation of COVID-19: Potential modulation by vitamin D. Nutrients. 2021, 13(7) – https://doi.org/10.3390/nu13030740

• Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate Medical Journal. 2021; 97(1149) – https://doi.org/10.1136/postgradmedj-2020-138712

• Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity. Journal of Medical Virology. 2021; 93(9) – https://doi.org/10.1002/jmv.27075

• Association of vitamin D Status with SARS-CoV-2 infection or COVID-19 severity: A systematic review and meta-analysis. Advances in Nutrition. 2021 – https://doi.org/10.1093/advances/nmab012

• Vitamin D and lung outcomes in elderly COVID-19 patients. Nutrients. 2021; 13(3) – https://doi.org/10.3390/nu13030717

• Does the high prevalence of vitamin D deficiency in African Americans contribute to health disparities? Nutrients. 2021; 13(2) – https://doi.org/10.3390/nu13020499

• Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. Journal of Medical Virology. 2021; 93(2) – https://doi.org/10.1002/jmv.26360

• Effectiveness of in-hospital cholecalciferol use on clinical outcomes in comorbid COVID-19 patients: A hypothesis-generating study. Nutrients. 2021; 13(1) – https://doi.org/10.3390/nu13010219

• The link between Vitamin D and COVID-19: Distinguishing facts from fiction. J Intern Med. 2021; 289(1) – https://doi.org/10.1111/joim.13158

• Association between Vitamin D deficiency and COVID-19 incidence, complications, and mortality in 46 countries: An ecological study. Health Security, 2020 – https://doi.org/10.1089/hs.2020.0137

• Vitamin D: A review and proposed evidence prevention in COVID-19. Vitamins and Minerals. 2020; 9:S8 – https://doi.org/10.23937/2469-567X/1510064

• The importance of Vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. Journal of Translational Medicine. 2020; 18 – https://doi.org/10.1186/s12967-020-02488-5

• The benefits of Vitamin D supplementation for athletes: Better performance and reduced risk of COVID-19. Nutrients. 2020; 12(12) – https://doi.org/10.3390/nu12123741

• Vitamin D insufficiency may account for almost nine of ten COVID-19 Deaths: Time to act. Comment on: “Vitamin D deficiency and outcome of COVID-19 patients”.  Nutrients 2020; 12, 2757. Nutrients, 12(12) – https://doi.org/10.3390/nu12123642

• Vitamin D3 as potential treatment adjuncts for COVID-19. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113512

• Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: The GERIA-COVID Quasi-Experimental Study. Nutrients. 2020; 12(11) – https://doi.org/10.3390/nu12113377

• Evidence regarding Vitamin D and risk of COVID-19 and its severity. Nutrients. 2020; 12(11) –  https://doi.org/10.3390/nu12113361

• Serum 25(OH)D level on hospital admission associated with COVID-19 stage and mortality. American Journal of Clinical Pathology. 2021; 155(3) – https://doi.org/10.1093/ajcp/aqaa252

• Role of Vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020; 13(10) – https://doi.org/10.1016/j.jiph.2020.06.021

• Does serum vitamin D level affect COVID-19 infection and its severity? A case-control study. Journal of the American College of Nutrition. 2020 – https://doi.org/10.1080/07315724.2020.1826005

• Vitamin D in prevention and treatment of COVID-19: Current perspective and future prospects. Journal of the American College of Nutrition. 2020 – https://doi.org/10.1080/07315724.2020.1806758

• Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized from COVID-19: A pilot randomized clinical study. J Steroid Biochem Mol Biol. 2020; 203:105751 – https://doi.org/10.1016/j.jsbmb.2020.105751

• Interaction between age and vitamin D deficiency in severe COVID-19 infection. Nutricion Hospitalaria. 2020; 37(5) – https://doi.org/10.20960/nh.03193

• Vitamin D supplementation in COVID-19 patients: A clinical case series. American Journal of Therapeutics. 2020; 27(5) – https://doi.org/10.1097/MJT.0000000000001222

• Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. The FEBS Journal. 2020; 287(17) – https://doi.org/10.1111/febs.15495

• Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PloS One. 2020; 15(9) – https://doi.org/10.1371/journal.pone.0239799

• Immune modulatory effects of Vitamin D on viral infections. Nutrients. 2020; 12(9): 2879 – https://doi.org/10.3390/nu12092879

• Impact of Vitamin D deficiency on COVID-19 – A prospective analysis from the CovILD Registry. Nutrients. 2020; 12(9): 2775 – https://doi.org/10.3390/nu12092775

• Vitamin D deficiency and outcome of COVID-19 patients. Nutrients. 2020; 12(9): 2757 – https://doi.org/10.3390/nu12092757

• Vitamin D insufficiency and deficiency and mortality from respiratory diseases in a cohort of older adults: Potential from limiting the death toll during and beyond the COVID-19 pandemic? Nutrients. 2020; 12(8) – https://doi.org/10.3390/nu12082488

• Vitamin D deficiency and co-morbidities in COVID-19 patients: A fatal relationship? NFS Journal. 2020; 20 – https://dx.doi.org/10.1016%2Fj.nfs.2020.06.001

• Immunologic effects of vitamin D on human health and disease. Nutrients. 2020; 12(7) – https://doi.org/10.3390/nu12072097

• Perspective: Improving vitamin D status in the management of COVID-19. Eur J Clin Nutr. 2020; 74 – https://doi.org/10.1038/s41430-020-0661-0

• Vitamin D and COVID-19: Do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020; 8(7) – https://doi.org/10.1016/S2213-8587(20)30183-2

• Vitamin D deficiency and the COVID-19 pandemic. J Glob Antimicrob Resist. 2020; 22 – https://doi.org/10.1016/j.jgar.2020.05.006

• The role of Vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020 – https://doi.org/10.1007/s40520-020-01570-8

• 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2.
  Nutrients. 2020; 12(5) – https://doi.org/10.3390/nu12051359