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September 20, 1938 – December 5, 2025
It is with profound sadness that we announce the passing of Dr. Hiroyuki Abe, MD, a distinguished pioneer in orthomolecular medicine and integrative cancer care, who died on December 5, 2025, at the age of 87, due to pneumonia.
Dr. Abe’s lifelong contributions to clinical medicine, research, and the advancement of nutritional therapies have left an indelible mark on our global medical community. His passion for improving patient outcomes through evidence-based, compassionate care distinguished him as a leader and mentor to countless physicians, researchers, and healthcare professionals.
Dr. Abe was a founding figure in orthomolecular and integrative oncology in Japan. After completing his medical education and surgical training, he devoted himself to advancing patient-centered medicine that combined conventional oncology with innovative supportive therapies, including high-dose intravenous vitamin C and other nutritional treatments.
In 1988, he established his medical foundation and subsequently the Tokyo Cancer Clinic, a place that became known not only for its comprehensive cancer care but also for its emphasis on quality of life and holistic patient support. Under his leadership, the Tokyo Cancer Clinic became a beacon of hope for many patients and families, offering compassionate care and multidisciplinary treatment approaches long before such models became widespread.
Dr. Abe’s influence extended beyond his clinic. He was a dedicated educator and a vocal advocate for orthomolecular medicine, tirelessly promoting the integration of nutrient-based therapies into mainstream care. He served as a board member of the IV Therapy Research Society, contributing his clinical insights, guiding research initiatives, and fostering international collaboration.
In recognition of his pioneering work and enduring impact, Dr. Abe was honored with induction into the Orthomolecular Medicine Hall of Fame, a testament to his commitment to advancing health through science, compassion, and innovation.
Those who knew Dr. Abe remember him not only for his intellectual rigor, clinical expertise, and visionary leadership, but also for his warm humanity, humility, and unwavering dedication to patients. He inspired many to think broadly about healing, to challenge convention wisely, and to serve with integrity.
Dr. Abe is survived by his family, colleagues, and a global community of practitioners whose lives and work were enriched by his example. His legacy will continue to inspire generations of clinicians and researchers devoted to integrative, patient-centered care.
We extend our deepest condolences to his family and all who had the privilege of knowing him. May his memory be a blessing and a lasting source of inspiration.
Author: Atsuo Yanagisawa, MD
